We’re pleased to announce the release of Ensembl 101, and the corresponding release of Ensembl Genomes 48. The highlights of this release include an update of the human gene annotation and new population frequency data along with 39 new genomes including a new sheep reference and crop cultivars.

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The SARS-CoV-2 pandemic presents a serious challenge to healthcare, economies and societies across the globe, one that has demanded an unprecedented scientific response. Projects across multiple disciplines are now re-directing their usual analytical efforts to meet this challenge head-on, and GENCODE are no exception. Our project produces human gene annotation, and we’re contributing to this scientific effort by re-examining human genes that may be relevant to viral infection and COVID-19 disease. We hope this work will support further research along these lines. For example, updated gene annotation could benefit studies to find disease-linked variants in patients with severe COVID-19 symptoms, including work by Genomics England and others.

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We’re pleased to announce the release of Ensembl 99, and the corresponding release of Ensembl Genomes 46. Along with updates of human gene annotation and variation data, we have a menagerie of new and updated vertebrate species in Ensembl plus a whole set of new plants, mosquitos and flies in Ensembl Genomes.

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We will make changes to the directory layouts of both the Ensembl Genomes FTP server (ftp://ftp.ensemblgenomes.org/pub/) and the Ensembl GRCh37 FTP server (ftp://ftp.ensemblorg.ebi.ac.uk/pub/grch37/) that may affect your pipelines. These changes will come into effect in Ensembl Genomes release 43/Ensembl release 96, which are scheduled for April 2019. Here are the details, so that you can plan any required updates to existing scripts and pipelines ahead of the releases.
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