Sign up for our virtual series covering the Ensembl genome browser and accessing Ensembl data via its REST API. Both workshops will be held from Tuesday to Thursday, with the browser course running from 11th to 13th July and the REST API course from 18th to 20th July (14:00 – 17:00 BST). Read on for more information and how to register.

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We have made a number of changes in Ensembl Compara Perl API and REST API endpoints. These changes allow Ensembl to handle non-unique member stable IDs when retrieving comparative genomics data via the APIs. These changes will come into effect in Ensembl release 110 and all old endpoints will be retired in release 112. Please continue reading if you regularly retrieve comparative genomics data via the Ensembl APIs.

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Ensembl VEP maps your variants to genes but what do those genes do?

The Gene Ontology (GO) annotates genes with molecular function, the cellular location in which the gene product functions and the biological process in which the gene product is involved. In addition to phenotype association information, which is only available for a few genes, we now show GO annotations to help guide variant prioritisation by providing an indication of the functionality a variant may affect.

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In Ensembl release 109, we introduce a new display that integrates experimentally verified interactions between genes, proteins, mRNA or other small molecules onto our gene pages. This adds an additional layer of data that enables deeper analysis into the ways species interact in a variety of contexts. So far, we have imported curated interactions from PHI-base, HPIDB, and PlasticDB for which we could find exact protein matches in Ensembl.

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