Ensembl 105 and Ensembl Genomes 52 are expected in October 2021. Check out what we’re up to, although we can’t guarantee everything listed here will make it into the final release.

New Assemblies and/or Annotation

Human

• Update to human frequency data VCF files to the latest release of NCBI ALFA release 2

Vertebrates

New assemblies:

• Marmoset (Callithrix jacchus) updated from ASM275486v1 to mCalJac1.pat.X
• Rat (Rattus norvegicus) updated from Rnor_6.0 to mRatBN7.1
• Orangutan (Pongo abelii) updated from PPYG2 to Susie_PABv2
• Dog (Canis lupus familiaris) reference genome changed from CanFam3.1 to ROS_Cfam_1.0 Labrador retriever
• Dog-Boxer (Canis lupus familiaris) updated from CanFam3.1 to Dog10K_Boxer_Tasha. 
• Olive baboon (Papio anubis) updated from Panu_3.0 to Panubis1.0

Fungi

New assemblies and data:

• 476 assemblies and gene annotations imported from the European Nucleotide Archive (ENA), expanding our representation of ascomycetes, basidiomycetes and others.
• 15 genomes originating from VEuPathDb’s fungal database, FungiDB
• A new fungal gene tree 
• A re-mapping of pathogen-host interaction phenotypes from PHI-base onto fungal genes

Plants

New assemblies:

• European Olive tree (Olea europaea)
• Yellow Sarson (Brassica rapa R-o-18)
• Hazel (Corylus avellana)
• Common Fig (Ficus carica) 
• Lettuce (Lactuca sativa)  
• Sunflower (Helianthus annuus) updated to HanXRQr2.0-SUNRISE assembly
• Barley reference genome updated to Morex V3 assembly with IPK and BaRT gene models
• Masking of repeated sequences in many plant genomes using Red
• Brassica rapa Chiifu-401-42 downgraded to extra cultivar in strain set
• Gene name synonyms from phytozome added for Chlamydomonas reinhardtii 
• Plant reactome cross-references have been added for Zea mays
• Centromere data added to Triticum aestivum 
• SIFT predictions added to VEP output data for several plant species with variation data
• De novo genes added for chromosome level Triticum aestivum cultivars from the wheat 10+ genome project                                        

Other Updates and Highlights

• Biotype correction for polymorphic pseudogenes.
• Retirement of Ensembl 85 archive site
• Decommissioning of REST API eQTL endpoint
• VariantRecoder REST service will now return: Variant names in other databases (UniProt, ClinVar, ClinGen Allele Archive), GA4GH, VRS representation and MANE annotation
• VariantRecoder web tool will now return: Variant names in other databases (UniProt, ClinVar, ClinGen Allele Archive) and MANE annotation
• Support for BCF files now available