You may have noticed our beta REST server has been retired. We have replaced it with our new service, http://rest.ensembl.org, and have a handy migration guide to help you update existing scripts. Details about the new server can be found in the article published in Bioinformatics. Some of the improvements include:

• New POST endpoints
• POST messages allow users to submit a list of inputs as a single request
  This is supported for the archive, lookup and vep endpoints
• The rate limit has been increased, with up to 15 requests per second allowed
  Combined with POST, we were able to process 1000 variants per second!
• New /variation endpoint to retrieve variation information linked to a gene or a transcript
• New /regulatory endpoint to retrieve data from the regulatory build
• HTTPS support for clients working with a secure environment

This server provides access to the latest data in Ensembl, including the new human build on the GRCh38 assembly. For those wishing to use data from the GRCh37 assembly, a dedicated server is available on http://grch37.rest.ensembl.org